In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise. Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults. The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.
The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C \> T and rs2854116 T \> C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound. As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C \> T and rs2854116 T \> C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. In addition, the investigators will further analyze the association with other biomarkers, such as body mass index, adiponectin and insulin resistance.
Study Type
OBSERVATIONAL
Enrollment
500
Far Eastern Memorial Hospital
New Taipei City, Taiwan, Taiwan
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis
Time frame: Oct 2013 ~ Dec 2014
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance
Time frame: Oct 2013 ~ Dec 2014
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.