The aim of this study was to investigate the effect of a 24- hrs L-arginine infusion on hemodynamic and on parameters of microcirculation in patients with peripheral arterial occlusive disease (PAOD).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
40
Medical University of Vienna
Vienna, State of Vienna, Austria
Change from baseline in temperature gradient at 3h post-surgery
One temperature probe is attached to the index finger of the lying patients, a second probe at the radial side of the forearm, midway between elbow and the wrist. Temperature gradient is calculated by subtracting the value obtained at the fingertip from the forearm value and expressed in °C.
Time frame: baseline and 3h post-surgery
Change from baseline in Laser Doppler blood perfusion imaging at 1h
Perfusion values are expressed as arbitrary perfusion units.
Time frame: baseline & 1h post-surgery
Change from baseline in Laser Doppler blood perfusion imaging at 2h
Perfusion values are expressed as arbitrary perfusion units.
Time frame: baseline & 2h post-surgery
Change from baseline in Laser Doppler blood perfusion imaging at 3h
Perfusion values are expressed as arbitrary perfusion units.
Time frame: baseline & 3h post-surgery
Change from baseline in Laser Doppler blood perfusion imaging at 24h
Perfusion values are expressed as arbitrary perfusion units.
Time frame: baseline & 24h post-surgery
Change from baseline in Laser Doppler blood perfusion imaging at 48h
Perfusion values are expressed as arbitrary perfusion units.
Time frame: baseline & 48h post-surgery
Change from baseline in asymmetric dimethylarginine (ADMA) at 3h
Asymmetric dimethylarginine is measured by ELISA and expressed in µmol/l.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: baseline & 3h post-surgery
Change from baseline in asymmetric dimethylarginine (ADMA) at 24h
Asymmetric dimethylarginine is measured by ELISA and expressed in µmol/l.
Time frame: baseline & 24h post-surgery
Change from baseline in asymmetric dimethylarginine (ADMA) at 48h
Asymmetric dimethylarginine is measured by ELISA and expressed in µmol/l.
Time frame: baseline & 48h post-surgery
Change from baseline in plasma arginine concentration at 3h
L-arginine concentration is measured by HPLC and expressed in µmol/l.
Time frame: baseline & 3h post-surgery
Change from baseline in plasma arginine concentration at 24h
L-arginine concentration is measured by HPLC and expressed in µmol/l.
Time frame: baseline & 24h post-surgery
Change from baseline in plasma arginine concentration at 48h
L-arginine concentration is measured by HPLC and expressed in µmol/l.
Time frame: baseline & 48h post-surgery
Change from baseline in temperature gradient at 1h
One temperature probe is attached to the index finger of the lying patients, a second probe at the radial side of the forearm, midway between elbow and the wrist. Temperature gradient is calculated by subtracting the value obtained at the fingertip from the forearm value and expressed in °C.
Time frame: baseline & 1h post-surgery
Change from baseline in temperature gradient at 2h
One temperature probe is attached to the index finger of the lying patients, a second probe at the radial side of the forearm, midway between elbow and the wrist. Temperature gradient is calculated by subtracting the value obtained at the fingertip from the forearm value and expressed in °C.
Time frame: baseline & 2h post-surgery
Change from baseline in temperature gradient at 24h
One temperature probe is attached to the index finger of the lying patients, a second probe at the radial side of the forearm, midway between elbow and the wrist. Temperature gradient is calculated by subtracting the value obtained at the fingertip from the forearm value and expressed in °C.
Time frame: baseline & 24h post-surgery
Change from baseline in temperature gradient at 48h
One temperature probe is attached to the index finger of the lying patients, a second probe at the radial side of the forearm, midway between elbow and the wrist. Temperature gradient is calculated by subtracting the value obtained at the fingertip from the forearm value and expressed in °C.
Time frame: baseline & 48h post-surgery