The purpose of this study is to see whether the ICDs(Impulse Control Disorder) are improved and neuropsychiatric traits related to ICD are changed or not when switching dopamine agonist to levodopa/carbidopa in patients with Parkinson's disease who have been treated with dopaminergic medications.
* PRIMARY OBJECTIVE To evaluate the improvement of mMIDI(modified version of Minnesota Impulsive Disorders Interview,Korean version) score from the baseline to 12 weeks or LOCF(Last Observation Carried Forward) * SECONDARY OBJECTIVE i) To evaluate the improvement of neuropsychiatric profiles from the baseline to 12 weeks or LOCF ii) To evaluate the improvement of UPDRS(Unified Parkinson's Disease Rating Scale)Score from the baseline to 12 weeks or LOCF
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Treated for at least 6 months after diagnosis of Parkinson's Disease.
Sandoz Investigative Site
Anyang, South Korea
Sandoz Investigative Site
Daegu, South Korea
Sandoz Investigative Site
Pusan, South Korea
Sandoz Investigative Site
Seongnam, South Korea
Sandoz Investigative Site
mMIDI(modified Minnesota Impulsive Disorders Interview)
To evaluate the improvement of mMIDI(Korean version) score from the baseline to 12 weeks or LOCF(Last Observation Carried Forward)
Time frame: 12weeks
Neuropsychiatric profile
To evaluate the improvement of neuropsychiatric profiles from the baseline to 12 weeks or LOCF \* Neuropsychological assessment * General cognitive status: K-Minimental status exam(K-MMSE) * Psychiatric profile: * Neuropsychiatric inventory (K-NPI) * Beck depression inventory (BDI) * Barratt impulsiveness scale (BIS) * Beck anxiety inventory (BAI) * State-trait anger expression inventory (STAXI) * Obsessive compulsive inventory (OCI) * Evaluation of global change: * Patient global impression of improvement (PGI-I) * Clinical global impression of improvement (CGI-I)
Time frame: 12 weeks
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Seoul, South Korea