The Value of HBA in the Evaluation of Idiopathic Infertility

St. Luke's-Roosevelt Hospital Center35 enrolled

Overview

We would like to determine if HBA® testing of sperm in couples with presumed idiopathic infertility will reveal lower binding percentages than in couples with an identifiable cause of infertility either male factor or tubal factor We would like to determine if patients with abnormal HBA binding have decreased IVF outcome: decreases clinical pregnancy rate, implantation rate, and increased miscarriage rate

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

HBA binding assayOTHER

HBA binding assay will be preformed on the discarded portion of semen analysis used for IVF.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * . All groups will include females under 40 years of age undergoing 1st IVF cycle 3 groups 1. Abnormal Semen Analysis (sperm count \<10 million/ml and /or rapid progressive motility \< 50 %, WHO morphology \<30%) normal HSG , normal ovarian reserve testing and ovulation testing 2. Unexplained infertility- normal ovarian reserve testing and ovulation testing (FSH\< 10, AMH\>1.0) Normal ovulatory cycles, normal WHO semen analysis. Normal tubes on HSG or Laparoscopy 3. Tubal infertility as assessed by HSG or laparoscopy Exclusion Criteria: * women over 40, prior failed IVF

Locations (1)

The Continuum Reproductive Center

New York, New York, United States

Outcomes

Primary Outcomes

In each of these groups we will assess presence of HBA bound sperm

Time frame: immediate at time of preforming HBA test

Data from ClinicalTrials.gov

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