Single Dose Enteral Tranexamic Acid in Critically Ill Patients

Inclusion Criteria: * Critically ill patients admitted to ICU within 48 hours of onset of illness * Patients with feeding tubes (e.g., orogastric, nasogastric, PEG, etc.) Exclusion Criteria: * primary admitting diagnosis of cancer * primary admitting diagnosis of acute congestive heart failure * primary admitting diagnosis of chronic obstructive pulmonary disease (COPD) * primary admitting diagnosis of acute myocardial infarction or unstable cardiac arrythmia * primary admitting diagnosis of amyotrophic lateral sclerosis (ALS) or other non-infectious disease * primary admitting diagnosis of post-operative neurosurgical procedure * known hypersensitivity to tranexamic acid * acquired disturbances of color vision * hematuria cause by disease of the renal parenchyma * active thromboembolic disease such as deep venous thrombosis or pulmonary embolism * patients with known clotting disorders or other known bleeding disorders * recent (within 3 months) or active cerebrovascular bleed * pregnancy * inability to take study medicine (i.e., ileus with \> 500ml stomach residuals, NPO status) * patients excluded at the discretion of the treating physician