An Assessment of the Feasibility and Safety of Conservative Oxygen Therapy in Critically Ill Patients

Austin Health105 enrolled

Overview

The investigators hypothesize that it is feasible and safe to deliver a conservative approach to oxygen therapy in mechanically ventilated critically ill patients (a tiem frame of, on average,10 days).

1. Identify patients likely to require ventilation until the day after tomorrow (a time frame of 36 hours of average) 2. Deliver a conservative oxygen therapy protocol while in ICU (a time frame on average of 10 days) 3. Target an oxygen saturation between 90 and 92% 4. Adjust FiO2 to achieve target SaO2 at all times 5. Assess percentage of time patient is within target 6. Assess for safety of this approach

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

105

Conditions

Critical Illness

Interventions

conservative O2 therapyOTHER

target lower O2 saturation

standard careOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mechanical ventilation * expected to be ventilated until the day after tomorrow (a tiem frame of, on average 48 hours) Exclusion Criteria: * expected to be off mechanical ventilation today or tomorrow * carbon monoxide poisoning * necrotizing fasciitis

Locations (1)

Austin Hospital

Melbourne, Victoria, Australia

Outcomes

Primary Outcomes

Difference in PaO2/FiO2 ratio from baseline to worst value

Pao2/FiO2 ratio will be measured regularly and compared during standard care and the intervention period (a time frame of, on average, 10 days)

Time frame: 10 days

Secondary Outcomes

Lactate

blood lactate will be measured regularly and assessed during standard care and the intervention period

Time frame: 10 days

Data from ClinicalTrials.gov

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