Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Women

Inclusion Criteria: * Has given written consent prior to any trial-related activity is performed. * Female sex, aged 20 years or older. * At least 2 nocturnal voids every night in a consecutive 3-day period as documented in the diary during the screening period. * Has given agreement about contraception during the trial. Exclusion Criteria: * Showing symptoms of any of the following diseases: Interstitial cystitis; Overactive bladder, defined as \>6 daytime voids,≥1 urgency episode and ≥1 urge urinary incontinence episode per 24 hours as documented in the 3-day diary period; Severe stress urinary incontinence. * Psychogenic or habitual polydipsia. * Urinary retention or a post void residual volume in excess of 150 mL as confirmed by bladder ultrasound performed after suspicion of urinary retention. * Cancer. * A history of urologic malignancies or a history of cancer which has not been in remission for the last 5 years. * Genito-urinary tract pathology. * Neurogenic detrusor activity. * Suspicion or evidence of heart failure. * Uncontrolled hypertension. * Uncontrolled diabetes mellitus. * Hepatobiliary diseases: Aspartate aminotransferase \>80 U/L or alanine aminotransferase \>90 U/L; Total bilirubin \>1.5 mg/dL. * Renal insufficiency: Serum creatinine level \>0.82 mg/dL; Estimated glomerular filtration rate \<50 mL/min. * Hyponatraemia: Serum sodium level \<135 mEq/L. * Central or nephrogenic diabetes insipidus. * Syndrome of inappropriate antidiuretic hormone. * Obstructive sleep apnea. * Previous desmopressin treatment. * Treatment with another investigational product within the past 3 months. * Concomitant treatment with any prohibited medication. * Pregnancy, breastfeeding, or a plan to become pregnant during the period of the clinical trial. * Alcohol or substance abuse. * A job or lifestyle that may interfere with regular night-time sleep. * A mental condition, lack of decision-making ability, dementia, a speech handicap, or any other reason which, in the judgement of the investigator (sub-investigator), would impair the participation in the trial.