The number of people seeking treatment for marijuana-related problems is on the rise, yet there is no currently accepted medication proven to help them quit. Frequent marijuana users have reported that they have trouble sleeping when they try to quit, and that the loss of sleep can lead to relapse. This research is designed to measure the severity of sleep problems in people as they are trying to quit heavy use of marijuana, and to investigate whether extended-release zolpidem (Ambien CR®) can improve quit rates among people trying to stop using marijuana.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
127
nightly administration of zolpidem extended-release
a standardized 12-week therapy consisting of motivational enhancement therapy (MET) and cognitive behavior therapy (CBT) for treating cannabis use disorders will be administered to all study participants
Johns Hopkins University
Baltimore, Maryland, United States
Sleep Efficiency as Assessed by Percentage of Time Asleep While in Bed
Percentage of time asleep while in bed is measured using ambulatory polysomnography (PSG) equipment.
Time frame: Week 1 of treatment
Number of Participants With Cannabis Abstinence as Assessed by Urine Cannabis Testing
Qualitative urine cannabis testing outcomes of study participants; missing drop-outs presumed positive; Negative = THCCOOH \<50ng/mL via EIA.
Time frame: Week 12
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