Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression

Brown University181 enrolled

Overview

This study will examine the effects of a first-line treatment for major depressive disorder (MDD), interpersonal psychotherapy (IPT), among men and women prisoners.

The purpose of this 3-year randomized trial is to promote uptake of evidence-based treatment in criminal justice settings by conducting a fully-powered randomized effectiveness study that collects pilot implementation data, including cost-effectiveness data. Group IPT will be compared to treatment as usual (TAU) in a sample of 90 male and 90 female prisoners with MDD from 4 institutions, allowing us to explore gender effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

181

Conditions

Major Depressive Disorder

Interventions

Group IPT for Depression + TAUBEHAVIORAL

Interpersonal psychotherapy (IPT) will be administered in 20 group 90-minute sessions over 10 weeks and 4 individual sessions (before group starts, in the middle of the group, at the end of the group, and one month after the group ends). These sessions will focus on improving your relationships with others, building healthy relationships, setting goals, and increasing coping skills. Additionally, participants will receive standard prison mental health treatment, individual therapy, medication, etc.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meet all DSM-IV criteria for primary (non-substance induced) major depressive disorder * Expectation of at least 6 months of incarceration at baseline interview * Incarcerated for at least 4 weeks Exclusion Criteria: * Lifetime: * Bipolar disorder * Psychotic disorder * Are imminently suicidal * Cannot understand English well enough to understand the consent form or assessment instruments when read aloud

Locations (5)

Massachusetts Correctional Institute - Old Colony Correctional Center

Bridgewater, Massachusetts, United States

Massachusetts Correctional Institution - Framingham

Framingham, Massachusetts, United States

South Middlesex Correctional Center

Framingham, Massachusetts, United States

Massachusetts Correctional Institution - Norfolk

Norfolk, Massachusetts, United States

Outcomes

Primary Outcomes

Change from Baseline in Hamilton Rating Scale for Depression (HRSD) at 3 Months

Time frame: 3 Months from Baseline

Secondary Outcomes

Change from Baseline in Suicidality at 3 Months

Suicidality as measured by the Beck Scale for Suicide Ideation.

Time frame: 3 Months from Baseline

Change from Baseline in In-Prison Functioning at 3 Months

In-prison functioning will be assessed by the number of correctional programs enrolled/completed and disciplinary/incident reports (measured by the Timeline Followback); aggression/victimization (measured by the Conflict Tactics Scale 2); social support (measured by the Multidimensional Scale of Perceived Social Support and the UCLA Loneliness Scale)

Time frame: 3 Months from Baseline

Change from Baseline in Hamilton Rating Scale for Depression (HRSD) at 6 Months

Time frame: 6 Months from Baseline

Change from Baseline in Suicidality at 6 Months

Suicidality as measured by the Beck Scale for Suicide Ideation.

Time frame: 6 Months from Baseline

Change from Baseline in In-Prison Functioning at 6 Months

Time frame: 6 Months from Baseline

Cost-effectiveness

Cost-effectiveness based on costs of IPT and TAU, improvements in HRSD scores, LIFE scores, and cost-offsets, including medical costs, programs completed, fewer fights, fewer suicide attempts, and reduced length of incarceration due to more "good time."

Data from ClinicalTrials.gov

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