The provision of analgesia to patients in pain is a fundamental necessity of emergency department practice and is usually accomplished using IV opioids. However, significant barriers exist to the provision of timely analgesia by the IV route. The use of the IN route for medication delivery provides an efficient and relatively painless mode of analgesia delivery. As well, ketamine is well-known to be an effective analgesic and to preserve cardiorespiratory function thus removing the necessity of physiologic monitoring that is obligatory when using opioids. The use of ketamine by the IN route provides a rapid, easy-administered and well-tolerated method for providing analgesia in the ED setting.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Lions Gate Hospital
North Vancouver, British Columbia, Canada
Proportion of subjects achieving a 13mm or more reduction in pain as measured on a 100-mm VAS within 30 minutes.
Time frame: 30 minutes
Median maximum reduction in VAS pain score achieved within 30 minutes
Time frame: 30 minutes
Median time required to achieve a 13-mm reduction in VAS pain score
Time frame: 1 hour
Vital signs changes (ETCO2, O2sat, HR, RR, BP)
Changes in vital signs will be recorded every 5 minutes for 30 minutes, then every 10 minutes for 30 minutes
Time frame: 1 hour
Adverse effects as defined by SERSDA
SERSDA (Side Effect Rating Scale for Dissociative Anaesthesia) includes: fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing, changes in vision, mood change, generalized discomfort, and hallucination.
Time frame: 1 hour
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