Genetic Predictors of Renal Dysfunction Following Heart Transplantation

University of Colorado, Denver300 enrolled

Overview

Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Heart Transplantation Chronic Renal Insufficiency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * cardiac-only transplant * 18 years of age or older at the time of cardiac transplant * 1 year or more post-cardiac transplant * treatment with cyclosporine or tacrolimus following transplant Exclusion Criteria: * combined organ transplant * decisionally impaired * unable to read or speak English * unable or unwilling to provide written informed consent

Genetic Predictors of Renal Dysfunction Following Heart Transplantation

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes