The main objective of this work is to conduct a clinical trial in obese and non-obese individuals testing the ability of low-fat dairy yogurt to improve gastrointestinal health and reduce chronic inflammation. Our central hypothesis is that short and long-term consumption of low-fat dairy yogurt will reduce inflammation to a greater extent in obese individuals by improving intestinal barrier function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
128
Consumption of 12 oz of low fat dairy yogurt daily for 9 weeks
Consumption of 12 oz of low fat soy pudding daily for 9 weeks.
Department of Food Science, Babcock Hall
Madison, Wisconsin, United States
Plasma soluble cluster of differentiation 14 (sCD14)
Fasting plasma sCD14 (change from baseline)
Time frame: 0, 3, 6, and 9 wk
Fasting plasma interleukin-6 (IL-6)
Fasting plasma IL-6 (change from baseline)
Time frame: 0, 3, 6, 9 wk
Postprandial sCD14
Postprandial plasma sCD14 following a high-fat, high-calorie challenge meal (area under curve)
Time frame: 0 and 9 wk
Postprandial interleukin-6 (IL-6)
Postprandial plasma IL-6 following a high-fat, high-calorie challenge meal (area under curve)
Time frame: 0 and 9 wk
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