This trail aims to evaluate the efficacy of acupoints on the specific meridian for chronic stable angina pectoris, compared with acupoints on the other meridian, sham acupoints and waiting-list. And to confirm the specificity of acupoints on meridian.
The basis of acupuncture is the theory of meridians and acupoints. Meridian and collaterals internally pertain to viscera, and externally spread over the extremities. An acupoint is the place where the visceral qi and meridian qi distributed in. besides acupoints are the stimulus points and reactive points for acupuncture to treat the diseases. Selecting the acupoints on the specific meridian is the basic principle of acupuncture. Recently, as to the existence of specificity of acupoints on the meridian has been questioned by many researchers. This trial using chronic stable angina pectoris as a carrier, select the acupoints on the hand shao yin heart meridian and hand jue yin pericardium meridian to treat chronic stable angina pectoris. Compared with acupoints on the other meridian and non-acupoints ,aiming to evaluate the efficacy, furthermore ,to confirm the existence of the specificity of acupoints on meridian.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
404
In each session, we treat bilaterally, 3 times a week and 2 days off a week, each patient in the acupuncture treatment groups will receive 12 sessions of acupuncture treatment over 4 weeks. The whole study period is 20 weeks including 4-week baseline period,4-week treatment period, and 12-week follow-up period. we will investigate at 0 day,4week,8week,12week,16week after randomization。
Each group in the basic treatment,Foundation treatment including health education and basic drug therapy. We recommend lifestyle modification for all patients. Modifications include increasing exercise; limiting alcohol consumption; and weight loss; quit smorking etc. Basic medication: Aspirin: 100mg qd; Metoprolol:25mg bid; Ramipril:5mg qd; Atorvastatin:20mg qn.
Chengdu University of Traditional Chinese Medicine
Chengdu, Sichuan, China
Number of angina attacks
The frequency of angina attack during 4-week.
Time frame: 16 weeks after inclusion
The severity of angina ( VAS score)
The VAS score evaluation angina pain severity
Time frame: 0 day,4, 8, 12, 16 weeks after inclusion
The dosage of nitroglycerin
Time frame: 0 day,4, 8, 12, 16 weeks after inclusion
Six minute walk test
Six minute walk test in the evaluation of exercise tolerance
Time frame: 0 day and 4 weeks after inclusion
Dynamic ECG Observation of the changes of ST-T
Dynamic electrocardiogram in six minute walk test to do
Time frame: 0 day and 4 weeks after inclusion
The Seattle Angina Questionnaire ( SAQ ) score
Time frame: 0 day,4, 8, 12, 16 weeks after inclusion
self-rating anxiety scale
Time frame: 0 day,4, 8, 16 weeks after inclusion
The incidence of cardiovascular episode during the 4 months
The incidence of cardiovascular episode during the 4 months(develop into unstable angina, acute myocardial infarction, death)
Time frame: 4, 8, 12, 16 weeks after inclusion
Self-rating Depression Scale
Time frame: 0 day,4, 8, 16 weeks after inclusion
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