This is a prospective, validation study of a extempore made tracer compared with a commercial. Studies with tracer have no medical effects but are used for studying human physiology, in this case pharmacokinetic variables of endogenous albumin distribution and turnover at different levels of inflammation. 1. Primary Objective: \- Do the extempore made tracer 123-iodine labeled albumin an commercially manufactured SERALB-125 give identical values of calculated blood plasma volume and capillary leakage measured as transcapillary escape rate of albumin? 2. Secondary Objective: * How do three different measures of albumin turnover correlate in volunteers? * How do the pharmacokinetic parameters of endogenous albumin vary between the three study groups?
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
30
Compare and validate the method of measuring albumine turnover rate
Karolinska University Hospital, Huddinge
Stockholm, Sweden
Transcapillary Escape Rate (TER)of Albumin
Is the measured value for 123-I-HSA and 125I-HSA identical/equal regarded TER and plasma volume (PV)?
Time frame: 42 days
Fractional catabolic rate (FCR)
Non compartmental analysis (NCA) and AUC (time-conc) will be determine the pharmacokinetics like clearance, distribution volume and absolute catabolic rate
Time frame: 42 days
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