Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular Carcinoma in Cirrhotic Liver

Inclusion Criteria: * Age ≥18 years. * Cirrhotic liver demonstrated by typical liver dysmorphy on imaging and/or liver biopsy. * HCC with at least one lesion measuring more than 1 cm in diameter with a single dynamic imaging technique (CT or MRI), showing intense arterial uptake followed by washout of contrast in the venous-delayed phases, or diagnosed by biopsy. * Borderline resectable disease eligible for surgical resection or radiofrequency destruction. * No extra-hepatic dissemination. * ECOG Performance status \< 2. * Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. * Signed written informed consent (approved by an Independent Ethics Committee) obtained prior to any study specific baseline procedures. Exclusion Criteria: * Decompensated cirrhosis (Child Pugh B, C). * Extra-hepatic tumour spread. * Previous or concomitant malignancies within five years other than basal cell carcinoma of the skin. * Pregnancy, lactation or refusal to use adequate contraceptive measures (hormonal or barrier method of birth control, abstinence). * Pre-existing other hepatic disease (liver abscess, hepatic sarcoidosis or tuberculosis, sclerosing cholangitis, …). * Previous trans-arterial radioembolization (TARE). * History of allergic reactions attributed to compounds of similar chemical or biologic composition of the administered materials. * Bleeding diathesis, history of cardiovascular ischemic disease or cerebrovascular incident within the last six months. * Major surgery within four weeks. * Uncontrolled concurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Uncontrolled Diabetes.