Hypothesis: The investigators want to study whether parathyroid hormone improves healing of humerus after a fracture. The investigators will assess healing of the humerus with Constant score.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
72
100 micrograms of 1-84 parathyroid hormone daily for 8 weeks, subcutaneous injection.
Saline injection daily for 8 weeks.
Hvidovre Hospital
Hvidovre, Denmark
RECRUITINGChanges in constant score
Constant score summarizes the function of the arm using a questionnaire (activities of daily living - ADL) and functional testing of the arm.
Time frame: 5, 8, 11, 23, and 104 weeks.
Changes in Oxford Shoulder Score
Oxford shoulder score is a questionnaire that assesses the function of the arm through the evaluation of the participant.
Time frame: 5, 8, 11, 23, and 104 weeks.
Changes in bone formation evaluated by X-ray.
Time frame: 5, 8, 11, 23, and 104 weeks.
Changes in biochemical bone markers
sodium, potassium, creatinine, liver enzymes, vitamin D, parathyroid hormone, alkaline phosphatase, hemoglobin, magnesium, calcium, zinc.
Time frame: 0, 5, 25 weeks
Changes in regulatory T lymphocytes
Regulatory CD3+CD4+CD25+Foxp3+ T lymphocytes.
Time frame: 0, 8, 24 weeks
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