Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan. An ancillary study will evaluate the interest of blood predictive biomarkers.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SCREENING
Masking
DOUBLE
Enrollment
1,000
All subjects will receive a low-dose CT-scan, a blood test (ancillary study) and provide an induced sputum
Caen University Hospital
Caen, France
Le Havre Hospital
Le Havre, France
Rouen University Hospital
Rouen, France
Risk of false positive
Ratio of false positives (RFP) for detection of lung cancer in reference to conventional cytology analysis of sputum
Time frame: within 3 months
detection of lung cancer
Ratio of sensitivities for detection of lung cancer in reference to conventionnal cytology analysis of sputum
Time frame: within 3 months
Sensitivity for lung cancer detection compared with CT-scan
Ratio of sensitivity (RSN) for lung cancer detection in reference with CT scan. Interest of the combination "cytometry + CT-scan" compared with CT-scan alone will also be evaluated.
Time frame: within 3 months
Specificity for detection of lung cancer
Ratio of false positives (RFP) of automated cytometry analysis compared with CT-scan screening. The combination "automated cytometry + CTscan" will also be evaluated compared with CT scan alone.
Time frame: within 3 months
Predictive Biomarkers
Frequency of specific biomarkers at the time of screening. Links between lung cancer during 5 years of prospective follow-up.
Time frame: Annually during a maximum of 5 years
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