Dynamic Alterations of Tongue in Sleep Apnoea Hypopnea Syndrome During Sleep

Wenzhou Medical University41 enrolled

Overview

The aim of this study was to evaluate the dynamic changes of the tongue in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS) during sleep and while awake by using Ultrafast Magnetic Resonance Imaging (UMRI)

UMRI was undertaken on the upper airway in 21 OSAHS patients and 20 normal people after being deprived of sleep for one night. A series of midline sagittal images of the upper airway were obtained. The dynamic alterations of the tongue size and the distance from the tongue to X axis (an extended line from the anterior nasal spine to posterior nasal spine) and Y axis (a perpendicular line from the center of the pituitary to the X axis) were measured.Statistical comparisons between pairs of means were performed via t-tests using Spss10 software. A probability level of p\<0.05 was considered to be statistically significant.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obstructive Sleep Apnoea

Interventions

Ultrafast Magnetic Resonance ImagingDEVICE

MRI was performed with a 1.5 superconducting magnet (Gyroscan Intera type, Philips Co. Holland) in a posterior and anterior neck coil. The sequence used to perform the ultrafast MRI was a fast gradient- echo plus sequence. Technical parameters included: echo time, 12 msec; repetition time, 2.3 msec; flap angle, 250; matrix, 192 × 512; section thickness, 7 mm. The imaging time per slice for this sequence was 0.92 sec. A total of 120 consecutive images were obtained as a single section, with a total imaging time of 110.4 seconds. MRI scanning was carried out with the subject first asleep, then whilst awake after 20 minutes in quiet respiration. All images were inputted to the PACS workstation.

Eligibility

Sex: MALEMin age: 40 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients who are male 2. patients were diagnosed as OSAHS 3. patients underwent a thorough history (including the Epworth somnolence questionnaire) and physical examination 4. patients did not undergo any treatment 5. each subject gave written informed consent before entering the study. Exclusion Criteria: 1. patients didn't sign written informed consent 2. Any situation or condition that will interfere with adherence to study activities

Locations (1)

The Tenth Hospital Affiliated to Tongji University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

the distance from the tongue to X axis and Y axis

X axis is an extended line from the anterior nasal spine to posterior nasal spine ； Y axis is a perpendicular line from the center of the pituitary to the X axis；

Time frame: one night

Secondary Outcomes

the tongue size

Time frame: one night

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.