Patients undergoing surgery in beach chair position (BCP) are at risk for cerebral ischaemia. The impacts of arginine vasopressin (AVP) on haemodynamics and cerebral oxygenation are evaluated during surgery in BCP.
Patients undergoing shoulder surgery in BCP under general anaesthesia are randomly allocated to receive i.v. normal saline (control group) or AVP 0.05 or 0.07 U kg-1 (AVP group, n = 15 each) 2 min before moving into BCP. Mean arterial pressure (MAP), heart rate (HR), jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) are measured before (pre-sitting in supine position) and after patients assumed BCP.
Study Type
OBSERVATIONAL
Enrollment
74
Vasopressins propofol vasopressins sevoflurane
Placebo propofol \& placebo sevoflurane
vasopressin propofol \& placebo propofol
Department of Anesthesiology and Pain Medicine
Gwangju, South Korea
The magnitude of decrease of mean arterial pressure
Continuously measure mean arterial blood pressure before and after position change. Calculate the magnitude of maximum decrease of mean arterial pressure from baseline
Time frame: Baseline (before positioning) and lowest value within 10 min into beach chair position
Jugular venous oxygen desaturation
Jugular venous oxygen saturation is continuously measured whether its saturation is decreased below 50% or/and 40% for longer than 5 min.
Time frame: Up to 30 min after the positioning
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vasopressins sevoflurane placebo sevoflurane