Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis

Inclusion Criteria: * Ages 18 or older * Previously established diagnosis of primary sclerosing cholangitis Exclusion Criteria: * American Society of Anesthesiologists class 4 or greater * Serum creatinine \>= 1.7 mg/dL, eGFR \<= 30 mL/min, or dialysis dependence * Serum hemoglobin \<= 7 g * Left ventricular ejection fraction \<= 30% * Dyspnea with minimal exertion (or supplemental oxygen dependence) * History of bone marrow disease * Prior recipient of organ transplantation * Ongoing chemotherapy * Obstruction of the upper GI tract * Pregnant or lactating * Inability to provide informed consent