The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage

Inclusion Criteria: 1. Women with unexplained recurrent miscarriages (2 or more consecutive). 2. All patients have normal uterine cavity diagnosed by HSG and /or hysteroscopy, normal semen analysis, normal thrombophilic profiles, no history of malformed 3. normal fetus in the previous miscarriages Exclusion Criteria: 1. Age above forty years old . 2. Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[IgG or IgM\]); other recognised thrombophilic conditions (testing according to usual clinic practice). 3. Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy). 4. Fibroids distorting uterine cavity . 5. Abnormal parental karyotype . 6. Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).