Diameter Changes of Retinal Vessels During Hypoxia

University of Aarhus58 enrolled

Overview

The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus Type 1 Diabetic Maculopathy

Interventions

COX inhibitorOTHER

Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated

L-NG-monomethyl arginine citrateOTHER

Intravenous administration of L-NMMA during recordings of diameter changes of retinal vessels

COX inhibitor + L-NG-monomethyl arginine citrateOTHER

Combination of interventions. Administration of an eye drop voltaren and 45 minutes later infusion with L-NMMA is started and recording of diameter changes of retinal vessels is performed

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetes type 1 without retinopathy * Diabetic retinopathy Exclusion Criteria: * Cardio-vascular disease * Lung disease * Pregnancy * Previous ocular disease other than retinal branch vein occlusion * Previous treatment with medications influencing on the intraocular pressure or the metabolism of nitric oxide or prostaglandins

Locations (1)

Department of Ophthalmology, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Diameter changes of retinal vessels

Comparing the differences of diameter changes occuring during each of the interventions.

Time frame: Examination day 1 and 2

Data from ClinicalTrials.gov

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