The investigators performed a double-blind parallel study in a group of Subjects Showing Erosive Gastritis who were given Hizikia Fusiformis Extract over a period of 4 weeks. Endoscopic observations were performed before and 4 weeks after the treatment, and the cure and improvement rates were investigated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
54
Hizikia Fusiformis extract(1.3g/d)
Placebo(1.3g/d)
Changes in Erosions
Erosions was measured in study visit 1(0 week) and visit 3(4 week). Gastric erosion occurs when the mucous membrane lining the stomach becomes inflamed.
Time frame: 4 weeks
Changes in Score of Erosions
Score of erosions(score 1-4) was measured in study visit 1(0 week) and visit 3(4 week). Score of erosions is assigned a score of between 1 (Erosion = 0) to 4 (Erosion ≥ 6) and summed to form a score ranging from 1 (best) to 4 (worst).
Time frame: 4 weeks
Changes in Subjects' Symptoms Total Score
Subjects' symptoms total score(score 0-24) was measured in study visit 1(0 week) and visit 3(4 week). The original index consists of 8 Questions. Individual question response is assigned a score of between 0 (none) to 3 (moderate) and summed to form a score ranging from 0 (best) to 24 (worst).
Time frame: 4 weeks
Changes in Gastrin
Gastrin was measured in study visit 1(0 week) and visit 3(4 week).
Time frame: 4 weeks
Changes in PepsinogenⅠ
PepsinogenⅠ was measured in study visit 1(0 week) and visit 3(4 week).
Time frame: 4 weeks
Changes in PepsinogenⅡ
PepsinogenⅡ was measured in study visit 1(0 week) and visit 3(4 week).
Time frame: 4 weeks
Changes in Pepsinogen Ⅰ/Ⅱ Ratio
Pepsinogen Ⅰ/Ⅱ ratio was measured in study visit 1(0 week) and visit 3(4 week).
Time frame: 4 weeks
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Changes in Hs-CRP(High Sensitivity C-reactive Protein)
Hs-CRP(High Sensitivity C-reactive Protein) was measured in study visit 1(0 week) and visit 3(4 week).
Time frame: 4 weeks