We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
22
Oulu University Hospital
Oulu, Finland
Systolic ambulatory blood pressure
Systolic blood pressure measured with ambulatory blood pressure monitor.
Time frame: On day 8 of each arm
Diastolic ambulatory blood pressure
Diastolic blood pressure measured with ambulatory blood pressure monitor
Time frame: On day 8 of each arm
Systolic and diastolic blood pressure
Time frame: On day 9 of each arm
Pulse (ambulatory)
Time frame: On day 8 of each arm
Plasma renin activity
Time frame: On day 9 of each arm
Serum aldosterone
Time frame: On day 9 of each arm
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