Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

Samsung Medical Center74 enrolled

Overview

Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in clinical use. But there have been no reports about the effect of changing NMB agent on efficacy of MEP monitoring. Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Motor Evoked Potential Monitoring General Anesthesia

Interventions

MEP monitoring with continuous infusion of vecuronium during general anesthesiaOTHER

MEP monitoring with continuous infusion of vecuronium during general anesthesia

MEP monitoring with continuous infusion of cisatracurium during general anesthesiaOTHER

MEP monitoring with continuous infusion of cisatracurium during general anesthesia

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing neurosurgery with intraoperative motor evoked potential monitoring Exclusion Criteria: * Patients who can not undergo motor evoked potential monitoring due to central or peripheral neuromuscular disease (e.g. Cerebral palsy, Myasthenia gravis, Acute spinal injury, neurologic shock) * Patients with hepatic or renal disease with altered metabolism of vecuronium * Patients with medication which influence the metabolism of vecuronium (e.g. calcium channel blocker, aminoglycoside antibiotics, Lithium, MgSO4)