Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

Vanderbilt University28 enrolled

Overview

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Coronary Artery Disease

Interventions

AdenosineDRUG

Adenosine will be infused into the brachial artery at 0.125 mg/min for 15 minutes and then at 0.5 mg/min for an additional 15 minutes,

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases 2. Not taking any regular medications 3. Able to provide signed consent prior to study participation. Exclusion Criteria: 1. History of asthma 2. Pregnancy 3. Exposure to an investigational drug in the last 2 months. 4. Known hypersensitivity to study medications

Locations (1)

Autonomic Dysfunction Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Interstitial levels of adenosine

Time frame: After each dose of intrabrachial adenosine

Data from ClinicalTrials.gov

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