Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers

Inclusion Criteria: * Healthy males or non pregnant, non lactating healthy females age 18-50 years; * Must be able to produce acceptable sputum sample by induction; * Must respond to ozone inhalation with a \> 10% increase in the absolute percentage of sputum neutrophils and the total neutrophils (neutrophils/gram sputum) must increase by at least 50% from the sputum neutrophil count at screening; * Volunteer is a non-smoker or ex-smoker of at least 12 months' duration prior to screening with a history of less than 1 pack per year. Exclusion Criteria: * Volunteers receiving chronic medication other than oral contraceptives; * Screening forced expiratory volume FEV1 is \< 80% of the predicted value for their age, gender, height and race and/or their FEV1/FVC ration is below 70%; * Volunteers with significant occupational exposure to respiratory irritants or toxins * Upper respiratory tract infection within 30 days of the first study day, or lower respiratory tract infection within the last 3 months; * Volunteers taking any medication that may affect the respiratory tract within 30 days of the first study day; * Volunteers with a history of asthma