Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery

Yonsei University40 enrolled

Overview

Although the aetiology of emergence agitation (EA) derives from multiple factors, it is a frequent side effect of sevoflurane anaesthesia in children. Dexmedetomidine, a potent selective α2-adrenergic agonist, can reduce the doses of hypnotics, opioids, analgesics, and anaesthetics that must be concomitantly administered. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements and recovery profiles with EA in children undergoing ambulatory surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Ambulation Difficulty

Interventions

DexmedetomidineDRUG

dexmedetomidine(vs saline) 1 mcg/kg iv bolus during 10minutes, and then, 0.1 mcg/kg/h dexmedetomidine(vs saline) was infused.

normal salineDRUG

Eligibility

Sex: MALEMin age: 1 YearMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class I * obtaining written informed consent from the parents * aged 1-5 years, and weighing \<20 kg who were undergoing ambulatory hernioplasty or orchiopexy Exclusion Criteria: * mental retardation * developmental delays * neurological or psychiatric illnesses * coagulation disorder * spinal anomalies * bilateral procedures

Locations (1)

Severance Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

the reduction rate of ET-sevo in achieving BIS scores from 45-50

Time frame: 2 hour(during whole operation period)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.