Safety and Pharmacokinetics of AVL-292 Following Multiple Doses and the Effect of Food on the Single-dose Pharmacokinetics of AVL-292

Inclusion Criteria: * Healthy male or female subjects of any ethnic origin between ages of 18 and 65 with a body mass index between 18 and 33 Exclusion Criteria: * Recent history (i.e., within 3 years) of any clinically significant neurological, gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, endocrine, hematological, dermatological, psychological, ophthalmological, allergic or other major disorders; * Use of any prescribed systemic or topical medication within 30 days of the first dose; * Use of any non-prescribed systemic or topical medication (including vitamin/mineral supplements and herbal medicines, e.g., St. John's Wort) within 7 days of the first dose administration; * Exposure to an investigational drug (new chemical entity) within 30 days prior to the first dose administration