Telbivudine Renoprotective Effect in Patients With HBV-related Liver Cirrhosis

Inclusion Criteria: Subjects eligible for enrolment in the study must meet all of the following criteria: * Aged between 18-75 years (inclusive). * Male or female. * Subjects with positive HBsAg for more than 6 months and anti-HBs negative regardless of HBeAg status , HBV DNA ≥2×103 IU/ml * Subjects with HBV-related liver cirrhosis, including compensated cirrhosis and decompensated, but only Child-Pugh A or B. * The ablility to understand and sign a written informed consent prior to any study related procedure and comply with the requirements of the study. Exclusion Criteria: * Subjects meeting any of the following criteria must not be enrolled in the study * Subjects with non-HBV cirrhosis * Co-infection with HAV/HCV/HDV/ HIV * Subjects who take nucleosides within 6 months * Kidney injury due to non-HBV factors * Inability to comply with study requirements as determined by the study investigator * Patients with very low GFR, who may need dialysis or renal transplantation