Phase 2 Study of TD-9855 to Treat Fibromyalgia

Inclusion Criteria: * • American College of Rheumatology (ACR) Diagnostic Criteria for Fibromyalgia (FM) * Informed consent * 18 to 65 years of age * Discontinue therapy with adrenergic-acting drugs, and certain other medications * Only acetaminophen or NSAID as rescue pain medication * No narcotic pain meds or benzodiazepines * Only non-benzodiazepines as rescue hypnotics Exclusion Criteria: * Any current psychiatric disorder, lifetime bipolar disorder, severe comorbid Axis II disorder, mental retardation, etc, as assessed by Mini International Neuropsychiatric Interview (MINI) * Major depression at screening by MINI when unable to be washed out of MDD meds (investigator or provider's judgment) * Risk of suicide (investigator opinion and/or C-SSRS) * Recent history of substance or alcohol abuse * BMI \<18 or ≥45 * Concurrent disease; pain for diagnosed illness other than FM; non-compliance; history of seizures; pheochromocytoma; glaucoma; CV disease; orthostatic hypotension or orthostatic tachycardia; untreated sleep apnea * Abnormal lab values (liver, kidney, thyroid, and others)