The purpose of this study is to determine how aromatase inhibitors (AIs) such as Arimidex, Aromasin or Femara affect a woman's oral health and oral health related quality of life. Patients, dental professionals and medical oncologists will benefit from a greater understanding of the best oral care follow up practices of breast cancer survivors using aromatase inhibitors.
OBJECTIVES: Primary This cross-sectional prevalence study seeks to investigate the incidence and severity of oral health changes, specifically of periodontal conditions, among breast cancer survivors and the ways in which these outcomes affect their quality of life. Secondary * To determine the prevalence and severity of oral conditions in postmenopausal women with early stage breast cancer using adjuvant AI therapy as compared to postmenopausal women not using adjuvant AI therapy. * To determine if adjuvant AI therapy use is associated with greater alveolar bone loss or increased levels of bone turnover biomarkers in postmenopausal women with cancer undergoing adjuvant AI therapy compared to postmenopausal women not receiving AI therapy. * To determine the oral health-related quality of life among postmenopausal women with early stage breast cancer who are receiving adjuvant AI therapy.
Study Type
OBSERVATIONAL
Enrollment
300
Michigan Center For Oral Health Research (MCOHR)
Ann Arbor, Michigan, United States
Periodontal diseases
Time frame: At the time of study visit
Alveolar bone loss using salivary and serum-derived bone markers.
Time frame: At the time of study visit
Oral Health Related Quality of Life (OHRQoL) assessed via questionnaire
Time frame: At the time of study visit
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