Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD

Stanford University54 enrolled

Overview

The present study will explore the effectiveness of a computer based neurobehavioral intervention in alleviating symptoms and improving emotion regulation in individuals with PTSD. It will increase understanding of psychopathology at a neural-circuit level and aid development of new non-pharmacological treatment for PTSD. The study is managed by the Etkin Lab at Stanford University in California, but participants from the entire US are welcome to participate as the study is delivered online.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Anxiety Depression

Interventions

Computerized Neurobehavioral InterventionBEHAVIORAL

Targeted, computerized interventions completed from the participants' own home on a computer.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * current PTSD * internet access Exclusion Criteria: * lifetime psychotic disorder, * past-year substance dependence

Locations (1)

Stanford University, Department of Psychiatry and Behavioral Sciences

Stanford, California, United States

Outcomes

Primary Outcomes

WebNeuro Computerized Cognitive and Affective Assessment Battery

Age and gender-normed Z scores for the following measures: Sustained attention accuracy, Sustained attention lapses, Sustained attention false alarms, Working memory capacity, Visual scanning speed, Inhibition executive control, Processing speed, Maze completion executive control accuracy, Maze completion executive control speed, Immediate verbal memory, Delayed verbal memory, Inhibitory motor control accuracy, Inhibitory motor control lapses, Facial affect identification accuracy (happy, fearful, angry, sad, and disgusted), Facial affect identification speed (happy, angry, fearful, sad, or disgusted), Facial affect identity recognition accuracy (happy, angry, sad, fearful, or disgusted), Facial affect identity recognition speed (happy, sad, angry, fearful, or disgusted), Emotional conflict reaction time slowdown, Regulation of emotional conflict reaction time slowdown

Time frame: Baseline and 3-month

Secondary Outcomes

Clinician-assessed PTSD symptoms

Total and symptom sub scale scores from the Clinician-Administered PTSD Scale for DSM-IV (CAPS)

Time frame: Baseline and 3-month

Data from ClinicalTrials.gov

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