Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.

Johannes Gutenberg University Mainz75 enrolled

Overview

The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis-, Fabry-patients and healthy controls. We want to investigate biomechanical characteristics of the cornea and their influence on the IOP-measurements.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mucopolysaccharidosis Fabry Disease

Eligibility

Sex: ALLMin age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * MPS I, II, IV, VI patients with at least grade 3 of corneal clouding (Couprie et al.) * Fabry patients with cornea verticillata \> grade 1 * Age ≥ 12 years * Patient is able to comply with the study procedure * Patient has consented to be in the trial * Ability to fixate a target Exclusion Criteria: * History of corneal transplantation or refractive surgery * Corneal pathologies other than MPS-associated corneal opacity * Corneal, conjunctival or intraocular inflammation

Locations (1)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg-

Mainz, Germany

RECRUITING

Outcomes

Primary Outcomes

agreement between ccIOP and GAT in MPS, Fabry and healthy controls

Evaluation of agreement between ccIOP and GAT in MPS, Fabry and healthy controls

Time frame: Sep 2013 (anticipated)

Data from ClinicalTrials.gov

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