Randomized Controlled Phase II Trial of Pre-operative Celecoxib Treatment in Breast Cancer

Inclusion Criteria: * Female patients suspected of having invasive breast cancer, \>1 cm in diameter, and in whom there is an indication for a core or incision biopsy * Age \<75 years at time of diagnosis * Patient willing and able to comply with the study prescriptions * Patient able to give written informed consent before patient registration/randomisation * Pre- and post-menopausal patients are eligible * Hormone receptor positive and negative patients are eligible * A negative pregnancy test in pre-menopausal women Exclusion Criteria: * HIV, HBV or HCV positivity * Known hypersensitivity to NSAIDs * A history of upper gastro-intestinal bleeding * Endoscopically proven upper gastro-intestinal ulceration * Patients using NSAIDs, including salicyclic acid * Systemic use of corticosteroids * A history or the presence of any other malignancy excepting adequately treated squamous cell skin cancer or in situ carcinoma of the cervix * Patients who have been treated with neo-adjuvant chemotherapy or hormone therapy