Response to Influenza Vaccine in Patients With Non-Hematologic Malignancies Receiving Chemotherapy

Inclusion Criteria: * Patients must have biopsy-confirmed non-hematological malignancy * Patients must be scheduled to receive cytotoxic chemotherapy (adjuvant or metastatic setting), excluding immunotherapy * Patients must be of age \>=18 years. * Patients must have an absolute lymphocyte count \>= 1,000/mcL immediately prior to influenza vaccination * Ability of the patient (or legally authorized representative if applicable) to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Patients who have already received the influenza vaccine during the season in which they are considered for eligibility will be excluded * History of allergic reactions attributed to compounds of similar chemical or biologic composition to the influenza vaccine or egg allergies * Previous history of Guillian-Barre syndrome within the previous 6 weeks to influenza vaccination * Patients must not be receiving chronic steroid therapy, defined as \>= 14 days, unless used as part of a chemotherapy regimen * Patients must not be on any other agents that can suppress the immune system * Planned concurrent therapy with radiation * Uncontrolled illness at time of enrollment or influenza vaccination including, but not limited to, ongoing or active febrile illness * Psychiatric illness/social situations that would limit compliance with study requirements * Known immunosuppression eg. history of organ transplantation or known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because they may not be able to mount an appropriate immune response * History of influenza-like illness, defined as a temperature \> 37.8 degree C with cough or sore throat starting October 1, 2011 throughout the duration of the study * Patient may not be scheduled to receive chemotherapy on a weekly basis.