Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease

N/ACompletedNCT01696708

Institut National de la Santé Et de la Recherche Médicale, France50 enrolled

Overview

The purpose of this project is to study brain energy profile evolution at different stages of the Huntington disease.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Huntington Disease

Interventions

31-Phosphorus RMN SpectroscopyOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * UHDRS \< 50 * Age \> 18 years * Ability to undergo MR scanning * Covered by french social security Exclusion Criteria: * Evidence of psychiatric disorder * Attendant neurological disorder * Contraindications to MRI (claustrophobia, metallic or material implants) * Severe head injury * Unable to understand the protocol * Pregnancy * Failure to give informed consent * Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent) * Unwillingness to be informed in case of abnormal MRI

Locations (1)

Brain and Spine Institute (ICM)

Paris, France

Outcomes

Primary Outcomes

Ratio of Inorganic Phosphate (Pi) over phosphocreatine (PCr): Pi/PCr

31P-MRS allows quantification of high-energy phosphate metabolites such as phosphocreatine and inorganic phosphate

Time frame: 2 years

Secondary Outcomes

Correlation between primary outcome measure and clinical parameters

Correlating a brain energy deficit with clinical parameters in Huntington patients such as the Unified Huntington's disease rating scale (UHDRS) and total functional capacity score (TFC).

Time frame: 2 years

Study of longitudinal changes in Pi/PCr ratio over time.

Patients will be retested after one month.

Time frame: 2 years

Data from ClinicalTrials.gov

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