Web-based International Multi-Center Clinical Study for Parkinson's Disease

Seoul National University Hospital136 enrolled

Overview

The objectives of this study are (1) to compare the clinical outcome in correlation with the electrode positions estimated by web-based image fusion of the preoperative MRI and the postoperative brain CT taken at a stable period after surgery using mutual information technique in the patients with advanced Parkinson's disease (PD) after bilateral STN DBS and (2) to examine whether the documentation of the electrode position by using mutual information technique at a stable period after unilateral or bilateral STN stimulation provides useful information for the postoperative programming.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

136

Conditions

Parkinson Disease

Interventions

electrode positionPROCEDURE

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Advanced Parkinson Disease patients Exclusion Criteria: * The patients who have experienced any perioperative or postoperative complications * The patients with severe cognitive impairment, ongoing psychiatric problems, an unsatisfactory general condition for evaluation, or an inability

Locations (1)

Department of Neurosurgery, Seoul National University Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

To determine the electrode positions with the relationship of the STN from the fused images of the preoperative MRI and the postoperative CT

Time frame: at 1 month after surgery

Secondary Outcomes

UPDRS, H&Y, ADL scores, LEDD

Time frame: at 6 and 12 months after surgery

Data from ClinicalTrials.gov

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