Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI

Shanghai Institute of Acupuncture, Moxibustion and Meridian61 enrolled

Overview

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease. Meanwhile, the investigators aim to evaluate the efficacy by functional magnetic resonance imaging.

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease. meanwhile, the investigators aim to evaluate the efficacy by functional magnetic resonance imaging. Through treating quiescent Crohn's disease by electroacupuncture or moxibustion therapies for 12 weeks, Compare the different brain activation by the different therapies and observe the correlation between brain activation and efficacy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Crohn's Disease CAM

Interventions

electroacupunctureOTHER

Patients receive electroacupuncture for 30 minutes with a stimulation frequency of 2 /100 Hz and a stimulation intensity varying from 0.1 to 1.0 mA.3 times per week,the duration is 12 weeks.

moxibustionOTHER

patients receive herbs-partitioned moxibustion for 2 cones，3 times a week for 12 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-50 years; * right-handed; * clinical remission (Crohn's Disease Activity Index \[CDAI\]≤150) for at least 6 months prior to the study; * C-reactive protein(CRP)\<10 mg/l; * erythrocyte sedimentation rate (ESR) \<20 mm/h * signing awritten informed consent form. Exclusion Criteria: * use of corticosteroids and psychotropic medications in the previous 30 days; * current or prior history of neurological or psychiatric disease based * on physicians' examination and questionnaires; * current or prior history of neurosurgery, head injury, cerebrovascular * insult, or brain trauma involving loss of consciousness; * learning disability; * claustrophobia; * presence of metallic implants in the body; * being pregnant or during lactation.

Locations (1)

Shanghai Institute of Acupuncture-Moxibustion and Merdian

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

CDAI

Crohn's Disease Activity Index

Time frame: 1 year

Secondary Outcomes

fMRI

Brain activiation tested by BOLD fMRI

Time frame: 1 year

IBDQ

Inflammatory Bowel Disease Questionnaire

Time frame: 1 year

Inflammatory factors

Intestinal mucosa of IL-6,IL-17,IL-23,etc

Time frame: 1 and a half years

Neurotransmitter

5-HT,DA,etc

Time frame: 1 and a half years

Data from ClinicalTrials.gov

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