Development of the Partial Pressure of Carbon Dioxide During Exercise and at Night in Patients With Chronic Obstructive Pulmonary Disease (COPD) IV

Schön Klinik Berchtesgadener Land75 enrolled

Overview

The aim of this study is to investigate the development of partial pressure of carbon dioxide during the 6-min walking test and during night in Chronic Obstructive Pulmonary Disease (COPD)-patients (GOLD stage IV). Therefore the partial pressure of carbon dioxide, oxygen saturation and the heart rate are registered by a device called "Sentec" during the mentioned periods. In addition a measurement of activity is realised by an activity monitor ("Sensewear").

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

6-minute walking test

Eligibility

Sex: ALLMin age: 30 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * COPD IV with and without a respiratory insufficiency * maximal paCO² of 55mmHg at admission (taken at rest by blood gas analysis without LTOT) Exclusion Criteria: * paCO² \> 55mmHg * non-invasive ventilation * acute exacerbation

Outcomes

Primary Outcomes

Increase of PaCO2 more than 5mmHg

Time frame: From time of starting 6-minute walking test until the time of PaCO2-increase of more than 5mmHg assessed up to 6 minutes.

Secondary Outcomes

Change of PaCO2

Time frame: From the beginning of the 6-minute walking test until peak PaCO2, assessed up to 6 minutes