Efficacy of Acupuncture and Moxibustion Treatment in Patients With Active Crohn's Disease

Shanghai Institute of Acupuncture, Moxibustion and Meridian92 enrolled

Overview

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of active Crohn's disease. meanwhile, we are aim to observe the content of Inflammatory factors and Neurotransmitter before and after acupuncture and moxibustion therapy. Through treating active Crohn's disease by acupuncture and moxibustion therapies for 12 weeks, we are aim to observe the efficiency and the probably change of Inflammatory factors and Neurotransmitter of colonic mucosa and we may elucidate the mechanism of the efficiency of acupuncture and moxibustion therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Crohn's Disease CAM

Interventions

Treatment GroupOTHER

patients receive herbs-partitioned moxibustion for 2 cones and acupuncture for 30 minutes，3 times a week for 12 weeks

Control GroupOTHER

patients receive shallow needing and bran-partitioned moxibustion with the stimulation same to the treatment group.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-70 years; * Crohn's Disease Activity Index \[CDAI\]\>150 and \<450; * not taking any medication or taking salicylates, prednisone ( dose≤ 15mg and at least have taken a month ), after entering the study the dose remained constant; * Not taking immunosuppressive agents or use " with " biological preparations within 3 months prior to entering the study * signing a written informed consent form. Exclusion Criteria: * Severe Crohn's disease patients or patients in remission ( CDAI \> 450 or \< 150 ); * The pregnancy or lactation period patients ; * patients associated with heart, brain, liver, kidney and hematopoietic system disease; * The psychiatric patients; * Patients with other serious diseases.

Locations (1)

Shanghai Institute of Acupuncture-Moxibustion and Merdian

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

CDAI

Crohn's Disease Activity Index

Time frame: 2 years

Secondary Outcomes

Inflammatory factors

Intestinal mucosa of Th17/Treg,IL-6,IL-17,IL-23,etc

Time frame: 2 years

Neurotransmitter

Intestinal mucosa of 5-HT,DA,SP,VIP and their receptors etc

Time frame: 2 years

IBDQ

Inflammatory Bowel Disease Questionnaire

Time frame: 2 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.