The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS. Findings from this study are expected to inform decision making so that resource utilization can be optimised.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
22,300
2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart
Long lasting Insecticide treated mosquito net
PAMVERC office
Muleba, Kagera, Tanzania
RECRUITINGPrevalence of malarial infection in children 6 months to 10 years
Time frame: 9 months post randomisation
Moderate to severe anaemia in children under 5 years
Time frame: 9 months post randomisation
Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years
Time frame: 6 months post randomisation
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