Prevention of Bladder Dysfunction in Acute Spinal Cord Injury

Inclusion Criteria: * Patients with documented acute, motor complete C6 to Th11 spinal cord injury * Patients can be included in the study less than four weeks after injury * Male or female, aged 18 to 80 years old * Patient weight \> 40 kg * Patient is able and willing to sign informed consent * Patient is able to complete all study requirements Exclusion Criteria: * Neurogenic detrusor overactivity with contractions greater than 40 cm H2O at first visit * History or evidence of previous urological abnormalities, disease or surgery, except bladder dysfunction after spinal cord injury * History of haematuria or ongoing haematuria, if the hematuria is determined to be a pathologic condition or is uninvestigated * Pregnancy or females of childbearing potential unwilling to use a reliable form of contraception * Breastfeeding * Known allergy to Onabotulinumtoxin A * Grave psychiatric disorder * Use of anti-platelet or anti-coagulant other than low molecular weight heparin (LMWH) or acetylsalicylic acid * Haemophilia or other clotting disorders that cause bleeding diathesis * Treatment with antimuscarinic medication within 3 months of randomization * Treatment with botulinum toxin of any serotype within 3 months of randomization * Patient has been immunized for any botulinum toxin serotype * Patient has any medical condition that may put the patient at increased risk with exposure to botulinum toxin including diagnosed myasthenia gravis, Eaton-Lambert syndrome or amyotrophic lateral sclerosis * Patient has any condition or situation, which, in the investigator's opinion, puts the patient at significant risk, could confound the study results, or may interfere significantly with the patient's participation in the study