Multi-electrode Radiofrequency Renal Denervation System Feasibility Study

Inclusion Criteria: * Individual is ≥ 18 and ≤ 80 years old. * Individual has an office systolic blood pressure of 160 mmHG or greater (≥ 150 mmHg for Type 2 diabetics) based on an average of 3 office/clinic blood pressure readings * Individual is adhering to a stable medication regimen including ≥ 3 anti-hypertensive medications(preferred that one is a diuretic) for a minimum of two weeks prior to screening. Exclusion Criteria: * Individual has an estimated glomerular filtration rate (eGFR) of \< 45 mL/min/1.73 m2 * Individual has type 1 diabetes mellitus * Individual requires chronic oxygen support or mechanical ventilation (e.g., tracheostomy, CPAP, BiPAP) other than nocturnal respiratory support for sleep apnea. * Individual has primary pulmonary hypertension. * Individual is pregnant, nursing or planning to be pregnant.