Change in Airway Responsiveness After Allergen Exposure

University of Saskatchewan11 enrolled

Overview

Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Allergic Asthma

Interventions

MannitolDRUG

Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine)

Methacholine ChlorideDRUG

Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * mild, allergic asthma * FEV1 greater than 70% predicted * methacholine PC20 less than or equal to 16mg/ml Exclusion Criteria: * known sensitivity to mannitol or other excipient * diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating * recent thoracic, abdominal or eye surgery * recent allergen exposure (4 weeks), respiratory infection (6 weeks) * current immunotherapy * pregnancy * history of anaphylaxis * use of asthma therapies other than short acting beta agonist

Locations (1)

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Outcomes

Primary Outcomes

Change from baseline in airway responsiveness three hours after allergen exposure

Time frame: Change from Baseline at 3 hours

Data from ClinicalTrials.gov

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