The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.

University of Copenhagen18 enrolled

Overview

The overall purpose is to explore the link between the gut and the bones by investigating meal stimulated changes in the blood level of a number of hormones and markers related to intestinal growth and bone turnover in patients undergoing surgery for obesity (gastric bypass). The hormones will be measured in blood samples taken before and after surgery. The results are compared with changes in body weight and body composition as measured by DEXA scanning.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Bone Loss

Interventions

Meal test and dexa scanOTHER

Body composition is determined by whole body deca scan and bone mineral density is determined dy dexa scans of the lumbar spine and the proximal femur.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Caucasians fulfilling the criteria for laparoscopic gastric bypass. * BMI\>40kg/m2. Exclusion Criteria: * Pregnancy * Chronic obstructive pulmonary disease * Diabetes mellitus * Chronic inflammatory bowel disease * Major psychiatric disorder * Drug abuse

Locations (1)

Hospital of Roskilde-Koege, The University of Copenhagen

Koege, Denmark

Outcomes

Primary Outcomes

Meal stimulated changes in gut hormones and bone markers.

Time frame: Before surgery and 4 weeks and 6 months after surgery.

Secondary Outcomes

Changes in bone mass and body composition.

Time frame: Before surgery and 6 months after surgery.

Data from ClinicalTrials.gov

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