Pharmacokinetic Study of Super-boosted Lopinavir/Ritonavir Given With Rifampin

* Antiretroviral naive * If not antiretroviral naïve they must meet the following criteria: * Taking Kaletra containing regimen with suppressed viral load. * Taking an NNRTI or integrase containing regimen without prior history of use of PI for more than 2 weeks * Taking an NNRTI or integrase containing regimen with prior exposure to PI greater than 2 weeks. It must be clearly stated in the source document that PI was switched to another agent for convenience. * Taking another PI containing regimens with suppressed viral load. It must be clearly stated in source document that if another PI was used for greater than 2 weeks the regimen was switched to another agent for convenience. Subjects with prior history of PI use may be enrolled, if there is a genotype showing no resistance to Kaletra Other Inclusion criteria * Be at least 18 years of age and able to give informed consent. * Diagnosed with TB by criteria per Brazilian Ministry of Health * Have a good clinical response to TB. * Tolerating tuberculosis therapy containing rifampin for the 2 weeks prior to screening,except for persons taking protease inhibitors at time of diagnosis of TB.,. Subjects taking protease inhibitors will be screened and initiate visit 1 within 3 days of starting TB medication * HIV positive with documentation present in source document. * Have a CD4 cell count greater than 50 cells/mm3if not taking ART. Persons with cd4 \< 50 may be enrolled, if it is felt that in the best interest of the patient, that enrollment in the study will allow for quicker initiation of antiretroviral therapy than referral to another treatment center. Exclusion Criteria: * Non-compliance with DOTPlus. Alternatively DOT can be done by telephoning patient on a daily basis 5 times a week and having patient annotate taking drug in a log which would be reviewed by clinic staff * History of being treated for tuberculosis in the prior 2 years unless there is DST, including PCR testing, showing sensitivity to rifamycin. * Known hypersensitivity to rifampin or rifabutin. * Liver enzymes greater than 2 times ULN. * Bilirubin greater than 2 times ULN. * Serum creatinine greater than 3 times ULN. * Hemoglobin less than 7.0 gms even if receiving erythropoietin. * Absolute neutrophil count less than 750 cells/mm3 even if receiving G-CSF. * Fasting triglycerides greater than 400 mg/dL. * Fasting cholesterol \> 1.6 upper limits of normal. * GI intolerance of tuberculosis medications requiring discontinuation of tuberculosis medications. * Fasting glucose greater 150 mg/dL. * Pregnant women. * Use of one of the prohibited medications * Any condition that the investigators feel could compromise the use of the current medication. * Have a CD4 cell count of 50 cells/mm3or less * Hepatitis B or C infection * Alcohol or illicit drug use, which in the investigators opinion may affect participation in study.