Safety, Tolerability, and Immunogenicity Study of Investigational Recombinant Botulinum Vaccine A/B (rBV A/B) in Volunteers Previously Immunized With Investigational Pentavalent Botulinum Toxoid

Inclusion Criteria: * The volunteer has received pentavalent botulinum toxoid for occupational protection under BB IND 0161, with the previous pentavalent botulinum toxoid dose at least 6 months prior to the planned rBV A/B dose. * The volunteer is between the ages of 18 and 69 years at the time of consent. * The volunteer is healthy and has an acceptable medical history. * The volunteer meets the subject suitability requirements and recommendations for source plasma donors (for Part 2 subjects only). * The volunteer, if female and of childbearing potential, is not pregnant or lactating, and agrees to use an acceptable form of FDA-approved contraception for the duration of the study. * The volunteer has the ability to understand the requirements of the study and provide informed consent. * The volunteer agrees to complete the subject diary on a daily basis for 7 days post-vaccination and to report concomitant medication and adverse events during the study period. * The volunteer provides written authorization for use and disclosure of protected health information. * The volunteer agrees not to donate blood or blood products (outside of study procedures) during the course of the study. * The volunteer has personal health insurance. Exclusion Criteria: * Be pregnant or nursing * The volunteer has a history of laboratory evidence of syphilis, acquired immunodeficiency syndrome, Creutzfeldt-Jakob disease, or infection with human immunodeficiency viruses 1 or 2, human T cell lymphotropic virus 1, hepatitis B virus, or hepatitis C virus. * The volunteer had prior severe local or severe systemic reaction to last immunization with pentavalent botulinum toxoid. * The volunteer has a known allergy to aluminum compounds, yeast, or other components of the vaccine. * The volunteer has donated one or more units of blood or undergone plasmapheresis within 28 days before screening. * The volunteer has received a blood product or immunoglobulin within 6 months of screening or plans to receive such products during the study. * The volunteer has received licensed nonliving vaccine within 14 days before study entry or licensed live vaccine within 60 days before study entry. * The volunteer has received investigational products (drugs, biologics, vaccines, or implantable devices) 60 days prior to study entry or plans to receive experimental products at any time during the study. * The volunteer has received prescription immunosuppressive or immunomodulatory agents, including parenteral, inhaled, or oral corticosteroids within 3 months before screening or plans on receiving such therapy at any time during the study with the exceptions (Subjects who have used prescription topical steroids may be enrolled 2 weeks after the therapy is completed; Intra-articular, bursal, or tendon injectable steroids are permitted; Any over-the-counter topical steroid use is permitted; Ophthalmic and intranasal steroids are permitted). * The volunteer has received cytotoxic therapy at any time in the previous 5 years to study entry. * The volunteer has an active systemic or recurrent disease that would place the subject at unacceptable risk of injury, require hospitalization, or require surgical intervention. * The volunteer has a history of alcohol or drug abuse within 12 months before screening. * The volunteer has past, present, or suspected illicit injection drug use. * The volunteer has inflammatory, vasculitic, or rheumatic disease, including systemic lupus erythematosus, polymyalgia rheumatica, rheumatoid arthritis, or scleroderma. * The volunteer has clinically recognized hepatic or renal insufficiency. * The volunteer has uncontrolled hypertension. * The volunteer has moderate to severe asthma, chronic obstructive pulmonary disease, or other significant pulmonary disease. * The volunteer has a seizure disorder. * The volunteer has moderate or severe illness or oral temperature of 100.4°F or greater within 3 days prior to immunization. * The volunteer is determined by the investigator to be unsuitable for participation in this trial for any reason.