The purpose of this study is to determine TD-1211 is processed by the body.
This study will provide information regarding the metabolic pathway of TD 1211, the need for evaluation of potential drug-drug interactions, the need for studies in special populations and the absolute oral bioavailability of TD-1211. The administration of radiolabeled drug is necessary to fully characterize the rates and routes of elimination of TD 1211, providing further quantitative information on the disposition of TD 1211. The results from this study will allow a more comprehensive comparison between animal and human routes of elimination and metabolic profiles of TD 1211.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Covance
Madison, Wisconsin, United States
Area under the plasma concentration versus time curve (AUC)
Time frame: 0 to 168 hours postdose
Peak plasma concentration (Cmax)
Time frame: 0 to 168 hours postdose
Time to peak plasma concentration (Tmax)
Time frame: 0 to 168 hours postdose
Half-life (T 1/2)
Time frame: 0 to 168 hours postdose
Percent total recovery of radioactivity in blood, urine, and feces
Time frame: 0 to 312 hours postdose
Number of participants with adverse events
Time frame: Baseline to 14 days
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