Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

University Hospital, Clermont-Ferrand80 enrolled

Overview

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Adult Patients Ventilated More Than 48 h Stable Respiratory and Hemodynamic Conditions for SBT Consent of Patients Arterial Line

Interventions

mechanical ventilationOTHER

Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

mechanical ventilationOTHER

Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions for SBT * Consent of patients * Arterial line Exclusion Criteria: * COBP * Laryngeal dyspnea * Tracheostomy * Arythmya * No echogenicity * Paraplegia \>T8

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Outcomes

Primary Outcomes

variations of lung ultrasound score

Time frame: 24 hours after extubation

Secondary Outcomes

Lung ultrasound score

Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

rates of patients with postextubation distress

Time frame: during the 48th post-extubation

Electrical Impedance tomography

Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

Epithelial and endothelial biomarkers

Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

Data from ClinicalTrials.gov

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